True incontinence? No, but it is possible to reduce your bladder capacity and train your brain to release automatically whenever you need to go (functional incontinence, similar to an unpotty trained toddler). However, this requires 24/7 diaper use and a concerted effort to "unpotty train" oneself, so it's not going to just happen unexpectedly after occasional or sporadic diaper use. Those who only sleep in diapers, wear them on long car trips or flights or occasionally for a weekend here and there do not have to worry about this.
Those who wear them for months on end or who go on long no-toilet jags do risk reducing their bladder capacity significantly and losing the ability to control their bladder... at least temporarily. This loss of control is entirely mental & does not indicate damage to bladder nerves or pelvic muscles, rather, it's a result of getting mentally comfortable letting go in a diaper. It's the same reason doctors advise against using the toilet every time you pass one "just in case"--it can make urgency worse, but this can be reversed with bladder training exercises.
The same applies here: if you're finding it harder to hold after a period of diaper use, add 5 additional minutes between each bathroom break to increase bladder capacity and take a break from diaper use and wetting until things return to normal. (Preferably on a weekend or during downtime at home when accidents won't be the end of the world). That is, assuming you don't WANT to lose bladder control. If unpotty training is the goal, check out my previous article on that topic. I also do individualized guides for $15 via email (complete with photos, links to secondary sources & much more) at my other gig here.
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